{"id":94815,"date":"2022-04-01T17:16:04","date_gmt":"2022-04-01T14:16:04","guid":{"rendered":"https:\/\/sanatate.md\/?p=94815"},"modified":"2022-04-01T17:16:04","modified_gmt":"2022-04-01T14:16:04","slug":"lsd-ul-poate-fi-eficient-in-tratamentul-anxietatii","status":"publish","type":"post","link":"https:\/\/sanatate.md\/ro\/lsd-ul-poate-fi-eficient-in-tratamentul-anxietatii\/","title":{"rendered":"LSD-ul poate fi eficient \u00een tratamentul anxiet\u0103\u021bii"},"content":{"rendered":"

Un studiu nou a constatat c\u0103 medicamentele psihedelice, cum ar fi dietilamina acidului lisergic, pot fi eficiente \u00een reducerea simptomelor anxiet\u0103\u021bii legate de stres \u0219i \u00een tratamentul altor maladii mintale.<\/h3>\n

Echipa de cercetare a studiului a fost condus\u0103 de dr. Gabriella Gobbi, profesor la Departamentul de Psihiatrie a Institutului de Cercetare al Centrului de S\u0103n\u0103tate al Universit\u0103\u021bii McGill din Montreal, Canada.<\/p>\n

\"\"<\/p>\n

Studiul, publicat \u00een revista Neuropsychopharmacology Trusted Source, a implicat \u0219i al\u021bi opt oameni de \u0219tiin\u021b\u0103 din domeniu \u0219i a implicat o colaborare \u00eentre canadieni, Universitatea Vita-Salute San Raffaele \u0219i Centrul de \u0218tiin\u021be Farmaceutice \u0219i Farmacologice de la Universitatea din Padova, Italia.<\/p>\n

Dr. Danilo De Gregorio, profesor asistent de farmacologie la Universitatea San Raffaele, a fost autorul principal al acestei lucr\u0103ri de cercetare. Studiile anterioare ale Dr. De Gregorio \u0219i Dr. Gobbi pentru indentificarea mecanismelor neurobiologice prin care LSD amelioreaz\u0103 anxietatea au fost evazive \u0219i neclare.<\/p>\n

Rezultatele studiului pe \u0219oareci<\/h3>\n

Cercet\u0103torii au administrat doze mici de LSD unui grup de \u0219oareci masculi, \u00een v\u00e2rst\u0103 de 8-12 s\u0103pt\u0103m\u00e2ni timp de \u0219apte zile, ce aveau o greutate de 25-30 de grame. \u0218oarecii au fost expu\u0219i la condi\u021bii cronice de stres, ca mai apoi s\u0103 primeasc\u0103 doze variabile de LSD.<\/p>\n

Rezultatele au ar\u0103tat c\u0103 administrarea intraperitoneal\u0103 de LSD nu a produs efecte antidepresive sau anxiolitice la \u0219oarecii nestresa\u021bi. Pe de alt\u0103 parte, administrarea dozei medii de LSD conform protocolului la \u0219oarecii stresa\u021bi, a prevenit comportamentele tipice anxiet\u0103\u021bii induse de stres \u0219i a diminuat modific\u0103rile celulare ale creierului.<\/p>\n

Administrarea repetat\u0103 de LSD a protejat, de asemenea, \u00eempotriva agrav\u0103rii anxiet\u0103\u021bii \u00een urma expunerii cronice la stres, ceea ce sugereaz\u0103 un efect anxiolitic al LSD-ului la administr\u0103ri repetate.<\/p>\n

Important de men\u021bionat c\u0103, de\u0219i dozele mici de LSD au activat doar transmiterea serotoninei prin fanta sinaptic\u0103, dozele mai mari au stimulat sistemul dopaminergic \u0219i au provocat efecte psihotice.<\/p>\n

Conform rezultatelor studiului, dozele mici de LSD m\u0103resc transmiterea sinaptic\u0103 a serotoninei, similar cu inhibitorii selectivi ai recapt\u0103rii serotoninei (SSRIs) \u2013 clas\u0103 de medicamente ce sunt utilizate \u00een mod obi\u0219nuit pentru tratamentul depresiei.<\/p>\n

Studii clinice<\/h3>\n

Studiile pe subiec\u021bi umani s\u0103n\u0103to\u0219i au indicat c\u0103 tratamentul cu LSD a indus sentimente de fericire, \u00eencredere, empatie, altruism \u0219i a indus interac\u021biuni sociale pozitive a subiec\u021bilor testa\u021bi, atunci c\u00e2nd este folosit ca adjuvant la psihoterapie. Participan\u021bii au raportat diminuarea simptomelor anxiet\u0103\u021bii \u0219i a stresului, timp de p\u00e2n\u0103 la 12 luni, dup\u0103 dou\u0103 sesiuni de psihoterapie asistat\u0103 cu LSD.<\/p>\n

Sunt necesare mai multe studii pentru a demonstra eficacitatea LSD-ului \u0219i mecanismele acestuia de ac\u021biune \u00een tratarea depresiei \u0219i a anxiet\u0103\u021bii. Studiile anterioare ale dr. Gobbi \u0219i colegilor ei, au explorat doar efectele secundare adverse ale LSD-ului.<\/p>\n

Efect pozitiv asupra conectivit\u0103\u021bii celulelor creierului<\/h3>\n

Studiul dr. Gobbi a descoperit c\u0103 dozele mici de LSD au promovat cre\u0219terea de noi termina\u021biuni dendritice la roz\u0103toare, care sunt termina\u021biuni neuronale \u0219i care transmit semnale electrice c\u0103tre alte celulele nervoase. Dendritele se pot deteriora din cauza stresului cronic \u0219i a anxiet\u0103\u021bii, astfel \u00eenc\u00e2t LSD-ul devine treptat un neuroprotector viabil, deoarece repar\u0103 aceste structuri la \u0219oarecii stresa\u021bi.<\/p>\n

Dr. Gobbi a declarat: \u201eAm fost surprin\u0219i de efectele neuroplastice ale LSD-ului, \u00een special de cre\u0219terea noilor sinapse la \u0219oarecii stresa\u021bi, ceea ce indic\u0103 faptul c\u0103 LSD-ul poate facilita neuroplasticitatea\u201d.<\/h3>\n

\u0410\u0432\u0442\u043e\u0440<\/strong> \u2013 Siluan Steg\u0103rescu<\/a>
\n\u0418\u0441\u0442\u043e\u0447\u043d\u0438\u043a<\/strong> \u2013 medicalnewstoday.com<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Un studiu nou a constatat c\u0103 medicamentele psihedelice, cum ar fi dietilamina acidului lisergic, pot fi eficiente \u00een reducerea simptomelor anxiet\u0103\u021bii legate de stres \u0219i \u00een tratamentul altor maladii mintale. Echipa de cercetare a studiului a fost condus\u0103 de dr. Gabriella Gobbi, profesor la Departamentul de Psihiatrie a Institutului de Cercetare al Centrului de S\u0103n\u0103tate […]<\/p>\n","protected":false},"author":594,"featured_media":94816,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[1293,1294],"tags":[7412,7413],"class_list":{"0":"post-94815","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-articole","8":"category-sanatate","9":"tag-lsd-ul","10":"tag-tratamentul-anxietatii"},"yoast_head":"\nLSD-ul poate fi eficient \u00een tratamentul anxiet\u0103\u021bii<\/title>\n<meta name=\"description\" content=\"Un studiu nou a constatat c\u0103 medicamentele psihedelice, cum ar fi dietilamina acidului lisergic, pot fi eficiente \u00een reducerea simptomelor anxiet\u0103\u021bii legate de stres \u0219i \u00een tratamentul altor maladii mintale.\" \/>\n<meta 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